Microfluidic channel device for tumor chemotherapy

Cancer chemotherapy can be very difficult for a patient, but if the cancer cannot be treated with chemotherapy, it is even more worrying. Soon, there may be a way to try different chemotherapy agents on a patient's tumor cells taken during a biopsy. Researchers at Purdue University, USA have developed a system of Microdiotomy Channels inside tumor cells exposed to therapeutic substances.

The device is named Tumor Microenvironment On Chip (T-MOC), about two inches (4.5 cm) on one side. Inside, tumor cells are developed according to a special matrix, resulting in a relatively natural 3D environment. Interstitial fluid flowing between tumor cells is also replenished to reproduce the best typical tissue environment. Furthermore, the team introduced the pharmacokinetics of the liver and kidneys to the system, eliminating the chemotherapy agent, and reducing its concentration, just like in the normal body.

The researchers tested the device when they discovered that doxorubicin, a drug commonly used in conventional chemotherapy, has treated two types of breast cancers. They did the same with mouse models of breast cancer and demonstrated that the Microflora Canal device could almost treat this animal.

More treatments need to be done in different types of cancer, as well as larger studies, but perhaps one day a oncologist will have an easier time choosing chemotherapy and pressure. use treatment.

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Translation summary: Dr.Nguyễn Hữu Tùng & Cộng sự