Low-dose colchicine, nonsteroidal anti-inflammatory drugs, and glucocorticoids delivered orally, intramuscularly, or intra-articularly are similarly effective for the treatment of acute gout flare-ups. Low-dose colchicine is similarly effective to high-dose colchicine but has fewer adverse effects. .

There is no definitive evidence-based A1C goal that will reduce periprosthetic joint infections for patients with diabetes who are preparing for total joint replacement. However, the risk of infection increases as the perioperative A1C level increases. Evidence suggests that a perioperative A1C level of less than 7.5 % may reduce the risk of such infections. .

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